Coronavirus COVID-19 | Viral Structure & Pathogenesis

Welcome to this video on the COVID-19 disease caused by the SARS-CoV-2 coronavirus.

In this tutorial we will discuss: 

- Structure of the SARS-CoV-2 virus and its structural glycoproteins

- ACE-2 receptor interaction and mechanisms of host cell entry

- Pathogenesis and mechanism of ARDS

- Typical chest radiograph and CT appearances

We hope you have found this video informative - see references below for further reading.

Peter & Jack

References used in the making of this video:

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2. Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge. Virol J. 2019 May 27;16(1):69.

3. Weiss SR, Navas-Martin S. Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus. Microbiol Mol Biol Rev. 2005 Dec;69(4):635–64.

4. Lin L, Lu L, Cao W, Li T. Hypothesis for potential pathogenesis of SARS-CoV-2 infection–a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect. 2020 Jan 1;9(1):727–32.

5. Frieman M, Baric R. Mechanisms of Severe Acute Respiratory Syndrome Pathogenesis and Innate Immunomodulation. Microbiol Mol Biol Rev. 2008 Dec 1;72(4):672–85.

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8. Walls AC, Park Y-J, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell [Internet]. 2020 Mar 9

9. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020 Feb 26;102433.

10. Guo Y-R, Cao Q-D, Hong Z-S, Tan Y-Y, Chen S-D, Jin H-J, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. 2020 Mar 13;7(1):11.

11. Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses. 2020 Apr;12(4):372.